apalutamide will minimize the extent or effect of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine that are CYP3A4 substrates can lead to reduced exposure to those remedies.darifenacin will boost the level or result of tr